Comparison of the Ames II and traditional Ames test responses with respect to mutagenicity, strain specificities, need for metabolism and correlation with rodent carcinogenicity
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چکیده
منابع مشابه
Comparison of the Ames II and traditional Ames test responses with respect to mutagenicity, strain specificities, need for metabolism and correlation with rodent carcinogenicity.
The Ames II Salmonella mutagenicity assay procedure was used to test 71 chemicals, and the results were compared with those from the traditional Ames Salmonella test using the NTP database as the reference. All Ames II tests were performed using a fluctuation procedure in microplate format, using TAMix for the detection of base pair substitutions and TA98 to detect frameshift mutations. There w...
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چکیده ندارد.
Ames II Mutagenicity Assay Technical Documentation
Statistical features of a base-specific Salmonella mutagenicity assay are considered in detail, following up on a previous Ž . report comparing responses of base-specific Salmonella Ames IIe strains with those of traditional tester strains. In addition to using different Salmonella strains, the new procedure also differs in that it is performed as a microwell fluctuation test, as opposed to the...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 2009
ISSN: 0267-8357,1464-3804
DOI: 10.1093/mutage/gep017